NF2 Research Labs

Below are some notable doctors and their research labs that are dedicated in analyzing the makeup and mechanism of NF2. Please consider contacting and donating to these labs to support their research in NF2.

  • Marco Giovannini, MD, PhD

    UCLA Head and Neck Surgery Research Lab
    Research topics include: Neurofibromatosis type 2, Schwannomatosis, Meningiomatosis, Rhabdoid Tumors

  • McClatchey Laboratory

    Harvard Med School / Massachusetts General Hospital (MGH)
    Research topics include: neurofibromatosis type 2; epidermal growth factor receptor (EGFR); cortical cytoskeleton; Ezrin, radixin, moesin (ERM proteins); polarity

    Principal Investigator: Andrea McClatchey, Ph.D.
    Phone: 617-726-5648

  • Di Tomaso Laboratory

    Harvard Med School / Mass. General Hospital (MGH) / Edwin L. Steele Laboratory for Tumor Biology
    Research topics include: vaascular physiology of neurofibromatosis type 2 tumors.

    Principal Investigator: Emmanuelle di Tomaso, Ph.D.
    Phone: 617-726-2178

  • Center for NF and Allied Disorders (CNFAD)

    Harvard Med School / Massachusetts General Hospital (MGH)
    CNfAD is a virtual center that spans the Harvard Medical School and affiliated hospitals (in Boston). The mission of CNfAD is to define the pathogenic mechanisms that cause NF1 and NF2 and to develop and test rational treatments for these disorders.

    Director: James F. Gusella, Ph.D.
    Email: gusella@helix.mgh.harvard.edu
    Phone: (617) 643-3388

  • Xandra O. Breakefield Laboratory

    Harvard Med School / Massachusetts General Hospital (MGH)
    The Breakefield laboratory uses molecular genetic techniques to elucidate the etiology of inherited neurological diseases and to develop vectors which can deliver genes to the nervous system for therapeutic purposes.

    Principal Investigator: Xandra O. Breakefield, PhD
    Lab Phone: 617-726-5728

  • Vijaya Ramesh, PhD

    Dana-Farber / Harvard Cancer Center / Mass. General Hospital (MGH)
    My laboratory focuses on understanding the pathophysiology of inherited cancer syndromes such as Neurofibromatosis 2(NF2) and Tuberous Sclerosis type 1 and type 2 (TSC1 and TSC2). The NF2 protein merlin belongs to a family of proteins that are known to connect the plasma membrane proteins to the actin cytoskeleton. One aspect of our work involves understanding the role of merlin in cellular signaling to the actin cytoskeleton…..

    Email: ramesh@helix.mgh.harvard.edu
    Phone: 617-724-9733
    Fax: 617-726-5736

  • Joseph Kissil, Ph.D. Lab

    The Scripps Research Institute, Scripps Florida
    Department of Cancer Biology
    “…Over the past several years we have focused on how ”contact-inhibition” triggers anti-proliferative/growth control signals. A central player in the process is a protein called Merlin, which is the product of the NF2 (neurofibromatosis type 2) tumor suppressor gene. Recent studies have indicated the NF2 allele is functionally inactivated in a broad range of tumors and has been shown to function as a key regulator of multiple signal transduction pathways including those regulated by small G-proteins and the Hpo/Yap pathway…”

    Email: jkissil@scripps.edu
    Phone: (561) 228-21702

  • Dr. C. Oliver Hanemann, MD, FRCP

    Peninsula Medical School and Dentistry, United Kingdom
    A primary human in vitro model to test and translate new therapies for Neurofibromatosis type 2 tumours into clinical trials.

    Email: oliver.hanemann@pms.ac.uk
    Phone: +44 1752 437419

  • Dr. Cristina Fernandez-Valle, Ph.D

    Burnett School of Biomedical Sciences, University of Central Florida

    Areas of Interest:…. molecular mechanisms controlling peripheral nerve development with emphasis on regulation of growth and differentiation of Schwann cells into myelin-forming cells

    Email: cfernand@mail.ucf.edu
    Phone: 407-266-7032
    Phone: 407-266-7033 (Lab)

  • Filippo Giancotti, MD, Ph.D,

    Memorial Sloan Kettering Cancer Center
    Our Areas of Interest:…. Merlin/NF2 in contact inhibition and tumor suppression

    Email: f-giancotti@ski.mskcc.org
    Phone: 212-639-8964
    Lab Phone: 212-639-7001 or 7044

  • Shanta Messerli, Ph.D.

    Marine Biological Laboratory
    Current research includes development and testing of signal blocking therapeutics to treat a variety of tumors whose growth depends on the kinase PAK1, including those associated with neurofibromatosis type 2 (NF2).

    Phone: (508) 289-7389
    E-mail: smesserli@mbl.edu

  • Molecular Neurosurgery Laboratory – Gene Therapy

    Harvard Med School / Mass. General Hospital (MGH) / Brain Tumor Research Center
    Research in this laboratory focuses on the use of herpes simplex virus (HSV) vectors for cancer therapy and gene delivery in the nervous system, with the long-term goal being the therapeutic application of these vectors to patients….Virotherapy for Neurofibromatosis.

    Director: Robert Martuza, MD
    Phone: 617-726-6817
    Fax: 617-643-3422

  • Jonathan Chernoff, MD, Ph.D,

    Fox Chase Cancer Center
    Overall focus of research is in uncovering the roles of protein phosphorylation in governing aspects of cancer biology. A research project is aimed at understanding Paks involvement in neurofibromatosis type 2 (NF2), an autosomal dominant disorder.

    E-mail: Jonathan.Chernoff@fccc.edu
    Office Phone: 215-728-5319
    Lab Phone: 215-728-5320